HEMATOPOIESIS Caspase-8 prevents sustained activation of NF- B in monocytes undergoing macrophagic differentiation
نویسندگان
چکیده
1Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Dijon, France; 2Institut Fédératif de Recherche (IFR) 100, University of Burgundy, Dijon, France; 3Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, Dijon cedex, France; 4Centre Hospitalier Universitaire, Dijon cedex, France; 5INSERM U567, Institut Cochin, Paris, France; 6Department of Hematology, Cochin Hospital, Paris, France; and the 7Department of Medicine and Biochemistry, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA
منابع مشابه
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Caspases have demonstrated several nonapoptotic functions including a role in the differentiation of specific cell types. Here, we show that caspase-8 is the upstream enzyme in the proteolytic caspase cascade whose activation is required for the differentiation of peripheral-blood monocytes into macrophages. On macrophage colony-stimulating factor (M-CSF) exposure, caspase-8 associates with the...
متن کاملCaspase-8 prevents sustained activation of NF- B in monocytes undergoing macrophagic differentiation
1Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Dijon, France; 2Institut Fédératif de Recherche (IFR) 100, University of Burgundy, Dijon, France; 3Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, Dijon cedex, France; 4Centre Hospitalier Universitaire, Dijon cedex, France; 5INSERM U567, Institut Cochin, Paris, France; 6Department of Hematology, Cochin Hospi...
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Arsenic trioxide (As(2)O(3)) is known to be toxic toward leukemia cells. In this study, we determined its effects on survival of human monocytic cells during macrophagic differentiation, an important biological process involved in the immune response. As(2)O(3) used at clinically relevant pharmacological concentrations induced marked apoptosis of human blood monocytes during differentiation wit...
متن کاملCaspase - 8 prevents sustained activation of NF - κ B in monocytes undergoing
Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Institut Fédératif de Recherche (IFR) 100, University of Burgundy; Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, 7 boulevard Jeanne d’Arc, 21079 Dijon cedex, France; Centre Hospitalier Universitaire, BP1542, 21034 Dijon cedex, France; INSERM U567, Institut Cochin; Department of Hematology, Cochin Hospital, ...
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The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within minutes the phosphorylation of its cytoplasmic tyrosine residues and the activation of multiple signaling complexes. Caspase-8 and -3 are activated at day 2 to 3 and contribute to macrophage differe...
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